Deubiquitinating enzymes (DUBs) are emerging as key factors for the infection of human cells by pathogens such as bacteria and parasites.In this review, we discuss the most recent studies on Touch Sensor the role of deubiquitinase activity in exploiting and manipulating ubiquitin (Ub)-dependent host processes during infection.The studies discussed
Syndecan-1 is a transmembrane heparan sulfate-bearing proteoglycan known to regulate multiple biological functions at the cell surface and within the extracellular matrix.Its functional activity can be modulated by heparanase, an enzyme that cleaves heparan sulfate chains and whose expression has been associated with an aggressive phenotype in many
Abstract Background Ventilator-induced lung injury (VILI) is a clinical complication of mechanical ventilation observed in patients with acute respiratory distress syndrome.It is characterized by inflammation mediated by inflammatory cells and their secreted mediators.Methods To investigate the mechanisms underlying VILI, a C57BL/6J mouse model was
ABSTRACT While recent research indicates that human health is affected by the gut microbiome, the functional mechanisms that underlie host-microbiome interactions remain poorly resolved.Metagenomic clinical studies can address this problem by revealing specific microbial functions that stratify healthy and diseased individuals.To improve our unders
Abstract Background The Seguro Popular (SP) was launched in 2004 to increase access to healthcare and reduce catastrophic expenditures among the Mexican population.To document the evidence on its effectiveness, we conducted a systematic review of impact evaluations of the SP.Methods We included papers using rigorous quasi-experimental designs to as